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Observation 4563

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Species Caenorhabditis elegans
Strain N2
Temperature 20
Lifespan 35 days
Reference Lifespan 35 days
Lifespan Change
Lifespan Measure median
Lifespan Effect increased
Significance significant
Citation Kaeberlein TL, Smith ED, Tsuchiya M, Welton KL, Thomas JH, Fields S, Kennedy BK, Kaeberlein M. (2006). Lifespan extension in Caenorhabditis elegans by complete removal of food. Aging Cell 5: 487-94. [pubmed]
DR-FD and mutation of eat-2 increase lifespan and thermotolerance by similar mechanisms. DR-FD increases the lifespan of eat-2(ad465) mutants, but not beyond that of wild-type. Median lifespans: N2 Fed, 25 days; N2 DR-FD, 35 days; eat-2 Fed, 29 days; eat-2 DR-FD, 35 days. There is no significant difference in DR in lifespan of eat-2 mutants and N2.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
eat-2 ad465 loss of function

Environment Interventions

Type Body
Caloric restriction Complete absence of bacterial food.