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Observation 45

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Species Drosophila melanogaster
Reference Lifespan
Lifespan Change 30%
Lifespan Measure mean
Lifespan Effect increased
Significance significant
Citation Orr WC, Sohal RS. (1994). Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.. Science 263: 1128-30. [pubmed]
The hypothesis that oxygen free radicals are causally involved in the aging process was tested by a study of the effects of simultaneous overexpression of copper-zinc superoxide dismutase and catalase. As compared to diploid controls, transgenic flies carrying three copies of each of these genes exhibited as much as a one-third extension of life-span, a longer mortality rate doubling time, a lower amount of protein oxidative damage, and a delayed loss in physical performance. Results provide direct support for the free radical hypothesis of aging.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
CAT over-expression
SOD1 over-expression