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Observation 4488

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Species Saccharomyces cerevisiae
Strain YPK9
Mating Type mata
Temperature 30
Lifespan 17.3 divisions
Reference Lifespan 21.2 divisions
Lifespan Change -18.4%
Lifespan Measure mean
Lifespan Effect decreased
Significance significant
Citation Kirchman PA, Miceli MV, West RL, Jiang JC, Kim S, Jazwinski SM. (2003). Prohibitins and Ras2 protein cooperate in the maintenance of mitochondrial function during yeast aging. Acta Biochim. Pol. [pubmed]
Details
Deletion of RAS2 decreases replicative lifespan by 18.4% in the absense of mitochondrial DNA (rho0). Deletion of RAS2 thus blocks the lifespan extension normally observed in rho0 strains.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
rho0 deletion / null 855625 View