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Observation 444

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Species Drosophila melanogaster
Strain rrf-3(pk1426)
Lifespan
Reference Lifespan
Lifespan Change 70%
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation Simonsen A, Cumming RC, Lindmo K, Galaviz V, Cheng S, Rusten TE, Finley KD. (2007). Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ub. Genetics 176: 1283-97. [pubmed]
Details

Loss-of-function mutation reduces maximum lifespan by 70%.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
dor RNAi knockdown 31118 View