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Observation 42

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Species Drosophila melanogaster
Sex male
Temperature 25
Lifespan 63.7 days
Reference Lifespan 45.1 days
Lifespan Change 41.24%
Lifespan Measure mean
Lifespan Effect increased
Significance significant
Citation Parkes TL, Elia AJ, Dickinson D, Hilliker AJ, Phillips JP, Boulianne GL. (1998). Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons.. Nat. Genet. 19: 171-4. [pubmed]
Overexpression of human SOD1 in the motorneuron, extends normal lifespan by up to 40% and rescues the lifespan of a short-lived Sod null mutant. Elevated resistance to oxidative stress suggests that the lifespan extension observed in these flies is due to enhanced RO metabolism.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
SOD1 human SOD1 driven by D42-GAL4 over-expression