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Observation 41

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Species Saccharomyces cerevisiae
Strain YPK9
Mating Type mata
Temperature 30
Lifespan 14.7
Reference Lifespan 15
Lifespan Change -2%
Lifespan Measure
Lifespan Effect decreased
Significance not significant
Citation Kirchman PA, Kim S, Lai CY, Jazwinski SM. (1999). Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae.. Genetics 152: 179-90. [pubmed]
Overexpression of the yeast genes for superoxide dismutase (SOD1) and cytoplasmic catalase (CTT1) in YPK9 (; mean 14.7) had no effect on life span (P = 0.4) compared to the same strain containing the empty vector (; mean 15.0). Overexpression was obtained on galactose-containing medium, which itself does not affect life span.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
SOD1 over-expression 853568 View
CTT1 over-expression