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Observation 40

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Species Drosophila melanogaster
Strain w1118
Sex male
Lifespan 36.91
Reference Lifespan 24.92
Lifespan Change 48.11%
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation Sun J, Tower J. (1999). FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophi. Mol. Cell. Biol. 19: 216-28. [pubmed]

Catalase overexpression significantly increased resistance to hydrogen peroxide but had neutral or slightly negative effects on the mean life span. Cu/ZnSOD overexpression extended the mean life span up to 48%. Simultaneous overexpression of catalase with Cu/ZnSOD had no added benefit, presumably due to a preexisting excess of catalase.

Other phenotypes: Targeted transgenic expression of hSOD1 in motorneurons alone causes 40% increase in mean and maximum life span [pubmed]. Targeted neuronal expression of SOD1 and CAT together abrogates life span extension by expression of SOD1 alone [pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
SOD1 over-expression