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Observation 39

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Species Caenorhabditis elegans
Strain N2
Sex hermaphrodite
Temperature 20
Lifespan 28.8 days
Reference Lifespan 21.6 days
Lifespan Change 33.33%
Lifespan Measure mean
Lifespan Effect increased
Significance significant
Citation Lakowski B, Hekimi S. (1998). The genetics of caloric restriction in Caenorhabditis elegans.. Proc. Natl. Acad. Sci. U.S.A. 95: 13091-6. [pubmed]
Details
Several mutations that reduce pharyngael pumping (eat mutants) increase life span in C. elegans.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
eat-1 ad427 loss of function