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Observation 3811

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Species Mus musculus
Strain
Lifespan 95
Reference Lifespan 121
Lifespan Change -21.49%
Lifespan Measure median
Lifespan Effect decreased
Significance significant
Citation Keyes WM, Wu Y, Vogel H, Guo X, Lowe SW, Mills AA. (2005). p63 deficiency activates a program of cellular senescence and leads to accelerated aging.. Genes Dev. 19: 1986-99. [pubmed]
Details
Heterozygous mice have a 27% shortened lifespan and display features of accelerated ageing.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
TRp63 loss of function