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Observation 3809

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Species Mus musculus
Strain
Lifespan 90 days
Reference Lifespan 200 days
Lifespan Change -55%
Lifespan Measure mean
Lifespan Effect decreased
Significance significant
Citation Varela I, Cadiñanos J, Pendás AM, Gutiérrez-Fernández A, Folgueras AR, Sánchez LM, Zhou Z, Rodríguez FJ, Stewart CL, Vega JA, Tryggvason K, Freije JM, López-Otín C.. (2005). Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.. Nature 437: 564-8. [pubmed]
Details
Knockout mice exhibit nuclear architecture abnormalities and signs of accelerated ageing.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Zmpste24 deletion / null