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Observation 38

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Species Saccharomyces cerevisiae
Strain W303AR5
Mating Type mata
Temperature 30
Lifespan 18.8
Reference Lifespan 21.4
Lifespan Change -12.15%
Lifespan Measure
Lifespan Effect decreased
Significance significant
Citation Kaeberlein M, McVey M, Guarente L. (1999). The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.. Genes Dev. 13: 2570-80. [pubmed]

Deletion of SIR4 results in a 20-25% reduction in life-span.

Other phenotypes: This reduction in life-span is suppressed by preventing mating type heterozygosity (co-expression of MATa and MATalpha.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
SIR4 deletion / null 851813 View