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Observation 37

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Species Saccharomyces cerevisiae
Strain W303AR5
Temperature 30
Lifespan 18
Reference Lifespan 21.4
Lifespan Change -15.89%
Lifespan Measure
Lifespan Effect decreased
Significance significant
Citation Kaeberlein M, McVey M, Guarente L. (1999). The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.. Genes Dev. 13: 2570-80. [pubmed]

Deletion of SIR3 shortens life-span by approximately 20%.

Other phenotypes: This reduction in life span by SIR3 is suppressed by preventing mating type heterozygosity.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
SIR3 deletion / null 851163 View