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Observation 3656

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Species Caenorhabditis elegans
Strain N2
Sex hermaphrodite
Temperature 20
Lifespan 21 days
Reference Lifespan 21 days
Lifespan Change
Lifespan Measure max
Lifespan Effect increased
Significance significant
Citation Boehm M, Slack F. (2005). A developmental timing microRNA and its target regulate life span in C. elegans. Science 310: 1954-7. [pubmed]
Details
RNA knockdown increases maximum lifespan relative to lin-4 maximum lifespan.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
lin-4 e912 loss of function
lin-14 RNAi knockdown