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Observation 35

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Species Caenorhabditis elegans
Strain N2
Sex hermaphrodite
Temperature 20
Lifespan 20.9 days
Reference Lifespan 18.3 days
Lifespan Change 14.21%
Lifespan Measure mean
Lifespan Effect increased
Significance significant
Citation Tissenbaum HA, Guarente L. (2001). Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.. Nature 410: 227-30. [pubmed]

Transgenic overexpression of sir-2.1 from an extrachromosomal or integrated multicopy array extends life span.

Other phenotypes: Life span extension is suppressed by a mutation in daf-16 and does not synergize with daf-2. Overexpression of sir-2.1 synergizes with the TGF-beta mutations daf-4 and daf-1 for dauer formation.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
sir-2.1 geEx1 over-expression 177924 View