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Observation 347

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Species Mus musculus
Strain
Lifespan
Reference Lifespan
Lifespan Change
Lifespan Measure
Lifespan Effect none
Significance
Citation Perez GI, Jurisicova A, Wise L, Lipina T, Kanisek M, Bechard A, Takai Y, Hunt P, Roder J, Grynpas M, Tilly JL. (2007). Absence of the proapoptotic Bax protein extends fertility and alleviates age-related health complications in female mice.. Proc. Natl. Acad. Sci. U.S.A. 104: 5229-34. [pubmed]
Details

Inactivation did not extend lifespan.

Other phenotypes: It also extended fertile potential and minimized age-related health problems, including bone and muscle loss, excess fat deposition, alopecia, cataracts, deafness, increased anxiety, and selective attention deficit.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
bax deletion / null