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Observation 3432

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Species Caenorhabditis elegans
Strain N2
Sex hermaphrodite
Temperature 20
Lifespan 70.1 days
Reference Lifespan 19.2 days
Lifespan Change 265.1%
Lifespan Measure mean
Lifespan Effect increased
Significance significant
Citation Hansen M, Hsu AL, Dillin A, Kenyon C. (2005). New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet. [pubmed]
Details
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Supplemental Table I was used since no experiment matched control was provided. RNA knockdown increased daf-2 lifespan by 82% relative to daf-2 lifespan alone.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
nuo-4 RNAi knockdown 176001 View
daf-2 (e1370)III loss of function 175410 View