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Observation 34

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Species Saccharomyces cerevisiae
Strain YB332
Mating Type mata
Temperature 30
Lifespan 15 divisions
Reference Lifespan 31 divisions
Lifespan Change -51.61%
Lifespan Measure mean
Lifespan Effect decreased
Significance significant
Citation Ashrafi K, Lin SS, Manchester JK, Gordon JI. (2000). Sip2p and its partner snf1p kinase affect aging in S. cerevisiae.. Genes Dev. 14: 1872-85. [pubmed]

Deletion of SIP2 shortens life span by about 50%. This decreased in life span is suppressed by deletion of SNF4

Other phenotypes: sip2 deletion strains show biomarkers of aging, including progressive sterility, enlargement and fragmentation of the nucleolus, redistribution of Sir3p to the nucleolus, and more rapid accumulation of ERCs [pubmed]. Null mutation causes an increase in the intracellular ATP and NAD+ levels in both young cells (generation 0-1) and older cells (generation 4), but the increase is greater in older cells [pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
SIP2 deletion / null 852664 View