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Observation 335

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Species Drosophila melanogaster
Strain
Lifespan
Reference Lifespan
Lifespan Change 56%
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation Simonsen A, Cumming RC, Brech A, Isakson P, Schubert DR, Finley KD. (2008). Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy 4: 176-84. [pubmed]
Details

Enhanced expression in older fly brains extended average adult lifespan by 56%.

Other phenotypes: Mutations resulted in reduced lifespan and increased sensitivity to oxidative stress. Over-expression increased resistance to oxidative stress.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Atg8a over-expression 32001 View