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Observation 31

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Species Saccharomyces cerevisiae
Strain W3031-A
Mating Type mata
Temperature 30
Lifespan 9.5 divisions
Reference Lifespan 24.5 divisions
Lifespan Change -61.22%
Lifespan Measure mean
Lifespan Effect decreased
Significance significant
Citation Sinclair DA, Mills K, Guarente L. (1997). Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants.. Science 277: 1313-6. [pubmed]
Details

Deletion of SGS1 shortens life-span approximately 60%.

Other phenotypes: Most cell death in sgs1 mutant cells is caused by a stochastic cell cycle arrest that is associated with a large-budded terminal morphology [pubmed]. Overexpression of SIR2 or deletion of FOB1 extend life-span of only those sgs1 mother cells that escape this arrest [pubmed][pubmed]. Overexpression of SGS1 extends the maximum life-span of cells lacking SRS2 but not the mean life-span [pubmed]. sgs1 mutants display other biomarkers of aging, including progressive sterility, fragmentation of the nucleolus, and movement of the Sir complex to the nucleolus [pubmed]. sgs1 mutants have greater rate of telomere loss than wild-type cell

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
SGS1 deletion / null 855228 View