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Observation 30

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Species Saccharomyces cerevisiae
Strain DBY746
Temperature 30
Lifespan 12 days
Reference Lifespan 9 days
Lifespan Change 33.33%
Lifespan Measure mean
Lifespan Effect increased
Significance significant
Citation Fabrizio P, Pozza F, Pletcher SD, Gendron CM, Longo VD. (2001). Regulation of longevity and stress resistance by Sch9 in yeast.. Science 292: 288-90. [pubmed]

Disruption of SCH9 extends chronological life span, as measured by stationary phase survival, up to 300%.

Other phenotypes: Deletion of SOD2 prevents the increased stationary phase survival caused by mutation of SCH9. [pubmed]. Deletion of SCH9 also increases restistance to heat shock and oxidative stress [pubmed] and increases replcative life-span by 18% [pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
SCH9 mTn non-null recessive 856612 View