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Observation 2885

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Species Caenorhabditis elegans
Strain N2
Sex hermaphrodite
Temperature 25
Lifespan 19.2 days
Reference Lifespan 19.2 days
Lifespan Change
Lifespan Measure mean
Lifespan Effect decreased
Significance significant
Citation Hansen M, Taubert S, Crawford D, Libina N, Lee SJ, Kenyon C. (2007). Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell 6: 95-110. [pubmed]
For calculating relative effect of lifespan in mutant background, an average of all N2 data in Table I was used since no experiment matched control was provided. RNA knockdown extended lifespan of fer-15;fem-1 mutants by 20% relative to fer-15;fem-1 mutant lifespan..

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
rps-26 RNAi knockdown
fer-15 b26 loss of function
fem-1 hc17 loss of function