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Observation 2562

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Species Mus musculus
Strain Jc1:ICR
Sex male
Lifespan 545 days
Reference Lifespan 525 days
Lifespan Change 3.81%
Lifespan Measure median
Lifespan Effect increased
Significance not significant
Citation Soda K, Dobashi Y, Kano Y, Tsujinaka S, Konishi F. (2009). Polyamine-rich food decreases age-associated pathology and mortality in aged mice. Exp. Gerontol. [pubmed]
Details

Feeding mice a diet high in polyamines increased median survival.

The spermine and spermidine concentrations in the low, normal, and high polyamine chows were 143 and 224 nmol/g, 160 and 434 nmol/g, and 374 and 1540 nmol/g, respectively. An increase in concentration of polyamine in the blood was found only in mice fed the high polyamine chow at 50 weeks of age. While the body weights of mice in all three groups were similar, the survival rate of mice fed high polyamine chow was significantly higher than those in the other two groups (p=0.011). Mice fed the high polyamine chow analyzed at 88 weeks of age, corresponding to the end of the study, demonstrated lower incidence of glomerulosclerosis and increased expression of senescence marker protein-30 in both kidney and liver compared to those fed the low polyamine chow.

Environment Interventions

Type Body
Low polyamine diet chow with 496 nmol/g putrescine, 224 nmol/g spermidine, 193 nmol/g spermine