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Observation 25

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Species Saccharomyces cerevisiae
Strain W303-1A
Mating Type mata
Temperature 30
Lifespan 19.1 divisions
Reference Lifespan 27 divisions
Lifespan Change -29.26%
Lifespan Measure median
Lifespan Effect decreased
Significance significant
Citation Austriaco NR, Guarente LP. (1997). Changes of telomere length cause reciprocal changes in the lifespan of mother cells in Saccharomyces cerevisiae.. Proc. Natl. Acad. Sci. U.S.A. 94: 9768-72. [pubmed]

Deletion of RIF1 shortens life span approximately 40%.

Other phenotypes: Deletion of RIF1 increases telomere length [pubmed]. The mechanism of life span shortening is likely due to recruitment of SIR2 from the rDNA to the telomeres [pubmed] [pubmed]. The sir4-42 allele suppresses the short life span of a rif1 mutant [pubmed].Deletion causes increased telomeric silencing and telomere length [pubmed][pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
RIF1 deletion / null 852578 View