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Observation 2282

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Species Mus musculus
Strain ICR/CD-1
Sex female
Lifespan 686 days
Reference Lifespan 644 days
Lifespan Change 6.52%
Lifespan Measure median
Lifespan Effect increased
Significance significant
Citation Arranz L, De Castro NM, Baeza I, Maté I, Viveros MP, De la Fuente M. (2010). Environmental enrichment improves age-related immune system impairment: long-term exposure since adulthood increases life span in mice. Rejuvenation Res 13: 415-28. [pubmed]
Environmental enrichment starting between 44-69 weeks of age increased life span and was efficient in improving the function (i.e., macrophage chemotaxis and phagocytosis, lymphocyte chemotaxis and proliferation, natural killer cell activity, interleukin-2 and tumor necrosis factor-alpha levels) and decreasing the oxidative-inflammatory stress (i.e., lowered oxidized glutathione content, xanthine oxidase activity, expression of Toll-like receptors 2 and 4 on CD4 and CD8 cells, and increased reduced glutathione and glutathione peroxidase and catalase activities) of immune cells.

Environment Interventions

Type Body
Environmental enrichment nvironmental enrichment consisted of two different objects included in the cages, which were changed every 2 days at 08:00 h. The rodent toys used were: orange bucket, jolly ball, hoop, holed ball, yellow tunnel, rough red object, yellow billard ball, and silver ball.