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Observation 2273

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Species Mus musculus
Strain UM-HET3
Sex female
Lifespan 920 days
Reference Lifespan 920 days
Lifespan Change
Lifespan Measure median
Lifespan Effect none
Significance
Citation Flurkey K, Astle CM, Harrison DE. (2010). Life Extension by Diet Restriction and N-Acetyl-L-Cysteine in Genetically Heterogeneous Mice. :. [pubmed]
Details
A heterogeneous stock of mice, UM-HET3 (the first generation offspring of CByB6F1/J and C3D2F1/J parents) were used to test effects of six antiaging treatments on life span. In the first report of diet restriction in a structured, segregating heterogeneous population, essentially the same increases in mean and maximum life span as found in CByB6F1/J hybrid positive controls were observed. The results of treatment with N-acetyl-L-cysteine started at 7 months, and aspirin, nitroflurbiprofen, 4-hydroxy phenyl N-tert-butyl nitrone, and nordihydroguaiaretic acid, all started at 16-18 months are also reported. Only male UM-HET3 mice receiving N-acetyl-L-cysteine had significantly increased life span, and this may have been due to treatment-related inadvertent diet restriction. The other agents had no significant effects on life span. The use of UM-HET3 mice helps assure that these results are not the result of unresponsiveness of a single genotype but that they more broadly represent laboratory mice.

Compound Interventions

Name Quantity Ncbi Id
N-acetyl-1-cysteine 5 g/L of drinking water