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Observation 2269

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Species Mus musculus
Strain UM-HET3
Sex male
Lifespan 1101 days
Reference Lifespan 831 days
Lifespan Change 32.49%
Lifespan Measure mean
Lifespan Effect increased
Significance significant
Citation Flurkey K, Astle CM, Harrison DE. (2010). Life Extension by Diet Restriction and N-Acetyl-L-Cysteine in Genetically Heterogeneous Mice. :. [pubmed]
A heterogeneous stock of mice, UM-HET3 (the first generation offspring of CByB6F1/J and C3D2F1/J parents) were used to test effects of six antiaging treatments on life span. In the first report of diet restriction in a structured, segregating heterogeneous population, essentially the same increases in mean and maximum life span as found in CByB6F1/J hybrid positive controls were observed. The results of treatment with N-acetyl-L-cysteine started at 7 months, and aspirin, nitroflurbiprofen, 4-hydroxy phenyl N-tert-butyl nitrone, and nordihydroguaiaretic acid, all started at 16-18 months are also reported. Only male UM-HET3 mice receiving N-acetyl-L-cysteine had significantly increased life span, and this may have been due to treatment-related inadvertent diet restriction. The other agents had no significant effects on life span. The use of UM-HET3 mice helps assure that these results are not the result of unresponsiveness of a single genotype but that they more broadly represent laboratory mice.

Environment Interventions

Type Body
Dietary restriction 66%–70% of the average amount eaten by ad-lib-fed mice of the same sex and age