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Observation 2184

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Species Saccharomyces cerevisiae
Strain BY4742
Mating Type matalpha
Temperature 30
Lifespan 30 days
Reference Lifespan 7 days
Lifespan Change 328.57%
Lifespan Measure median
Lifespan Effect increased
Significance significant
Citation Murakami CJ, Burtner CR, Kennedy BK, Kaeberlein M. (2008). A method for high-throughput quantitative analysis of yeast chronological life span. J. Gerontol. A Biol. Sci. Med. Sci. [pubmed]
Deletion of sir2, hst1, hst2, hst3, hst4 or all 5 sirtuins at the same time had no effect on chronological life span and did not reduce life span extension from dietary restriction at 0.5% or 0.05% glucose.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
HST3 deletion / null

Environment Interventions

Type Body
Dietary restriction Reduced glucose in the medium to 0.05%