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Observation 2102

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Species Mus musculus
Strain C57BL/6
Sex female
Lifespan 810 days
Reference Lifespan 830 days
Lifespan Change -2.41%
Lifespan Measure median
Lifespan Effect decreased
Significance not significant
Citation Enns LC, Morton JF, Treuting PR, Emond MJ, Wolf NS, McKnight GS, Rabinovitch PS, Ladiges WC. (2009). Disruption of protein kinase A in mice enhances healthy aging. PLoS ONE 4: e5963. [pubmed]

Disruption of the protein kinase A regulatory subunit RIIbeta increased life span in male, but not female, mice

Mutations that cause a reduction in protein kinase A (PKA) activity have been shown to extend lifespan in yeast. Loss of function of mammalian RIIbeta, a regulatory subunit of PKA expressed in brain and adipose tissue, results in mice that are lean and insulin sensitive.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Prkar2b deletion / null