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Observation 2101

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Species Mus musculus
Strain C57BL/6
Sex male
Lifespan 1005 days
Reference Lifespan 884 days
Lifespan Change 13.69%
Lifespan Measure median
Lifespan Effect increased
Significance significant
Citation Enns LC, Morton JF, Treuting PR, Emond MJ, Wolf NS, McKnight GS, Rabinovitch PS, Ladiges WC. (2009). Disruption of protein kinase A in mice enhances healthy aging. PLoS ONE 4: e5963. [pubmed]

Disruption of the protein kinase A regulatory subunit RIIbeta increased life span in male, but not female, mice

Mutations that cause a reduction in protein kinase A (PKA) activity have been shown to extend lifespan in yeast. Loss of function of mammalian RIIbeta, a regulatory subunit of PKA expressed in brain and adipose tissue, results in mice that are lean and insulin sensitive.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Prkar2b deletion / null