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Observation 2042

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Species Saccharomyces cerevisiae
Strain
Lifespan
Reference Lifespan
Lifespan Change 300%
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation Weinberger M, Feng L, Paul A, Smith DL, Hontz RD, Smith JS, Vujcic M, Singh KK, Huberman JA, Burhans WC. (2007). DNA replication stress is a determinant of chronological lifespan in budding yeast. PLoS ONE 2: e748. [pubmed]
Details
Mutants have a 3-fold reduced mean and maximum chronological lifespan under conditions of medium depletion.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
MEC1 loss of function