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Observation 2036

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Species Mus musculus
Strain
Sex female
Lifespan
Reference Lifespan
Lifespan Change 240%
Lifespan Measure mean
Lifespan Effect increased
Significance significant
Citation Cao L, Kim S, Xiao C, Wang RH, Coumoul X, Wang X, Li WM, Xu XL, De Soto JA, Takai H, Mai S, Elledge SJ, Motoyama N, Deng CX. (2006). ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency.. EMBO J. 25: 2167-77. [pubmed]
Details
Double mutants for chk2 extend lifespan of female mice hyopmorphic for Brca1 by at least 240%. Mice hypomorphic for Brca1 and double mutant for chk2 exhibit signs of premature ageing.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Chk2 loss of function