> Tools

Observation 2035

User Comments

Please login to leave comments.

Species Mus musculus
Strain Zmpste24-/-
Lifespan 140 days
Reference Lifespan 120 days
Lifespan Change 16.67%
Lifespan Measure median
Lifespan Effect increased
Significance significant
Citation Mariño G, Ugalde AP, Fernández AF, Osorio FG, Fueyo A, Freije JM, López-Otín C. (2010). Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function. :. [pubmed]

Zmpste24-/- knockout mice treated with recombinant human IGF-1 had their short life span extended.

Zmpste24 (also called FACE-1) is a metalloproteinase involved in the maturation of lamin A, an essential component of the nuclear envelope. Zmpste24-deficient mice exhibit multiple defects that phenocopy human accelerated aging processes such as Hutchinson– Gilford progeria syndrome.[pubmed]

Compound Interventions

Name Quantity Ncbi Id
Recombinant human IGF-1 1 mg/kg/day