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Observation 2032

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Species Mus musculus
Lifespan 20
Reference Lifespan 15
Lifespan Change 33.33%
Lifespan Measure mean
Lifespan Effect increased
Significance significant
Citation Choudhury AR, Ju Z, Djojosubroto MW, Schienke A, Lechel A, Schaetzlein S, Jiang H, Stepczynska A, Wang C, Buer J, Lee HW, von Zglinicki T, Ganser A, Schirmacher P, Nakauchi H, Rudolph KL. (2007). Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat. Genet. [pubmed]
Deletion of p21 prolongs the lifespan, about 45%, of telomerase-deficient mice with dysfunctional telomeres. Also improves the repopulation capacity and self-renewal of hematopoietic stem cells.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Cdkn1a deletion / null