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Observation 2002

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Species Mus musculus
Lifespan 52
Reference Lifespan 104
Lifespan Change -50%
Lifespan Measure mean
Lifespan Effect decreased
Significance significant
Citation Park DS, Cohen AW, Frank PG, Razani B, Lee H, Williams TM, Chandra M, Shirani J, De Souza AP, Tang B, Jelicks LA, Factor SM, Weiss LM, Tanowitz HB, Lisanti MP. (2003). Caveolin-1 null (-/-) mice show dramatic reductions in life span. Biochemistry 42: 15124-31. [pubmed]
Knockout mice are viable and fertile but exhibit an approximately 50% reduction in lifespan. Reduced lifespan is probably due to a combination of pulmonary fibrosis, pulmonary hypertension, and cardiac hypertrophy.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
cav1 loss of function