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Observation 2

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Species Caenorhabditis elegans
Strain Bristol N2
Sex hermaphrodite
Temperature 20
Lifespan 24.8 days
Reference Lifespan 18.8 days
Lifespan Change 31.91%
Lifespan Measure mean
Lifespan Effect increased
Significance significant
Citation Apfeld J, Kenyon C. (1999). Regulation of lifespan by sensory perception in Caenorhabditis elegans.. Nature 402: 804-9. [pubmed]

Recessive loss of function alleles can extend life span 100%.

Other phenotypes: Life span extension suppressed by gonad ablation but not germ line ablation [pubmed]. Mutants do not form dauers in response to starvation [pubmed]. Mutants have defective cilia [pubmed] and are defective in chemosensory response and chemotaxis [pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
osm-3 (n1540) non-null recessive 177141 View