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Observation 1999

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Species Mus musculus
Strain
Lifespan 1137 days
Reference Lifespan 1254 days
Lifespan Change -9.33%
Lifespan Measure max
Lifespan Effect decreased
Significance significant
Citation Zhang Y, Padalecki SS, Chaudhuri AR, De Waal E, Goins BA, Grubbs B, Ikeno Y, Richardson A, Mundy GR, Herman B. (2007). Caspase-2 deficiency enhances aging-related traits in mice. Mech. Ageing Dev. [pubmed]
Details
Loss of caspase-2 resulted in a shortened (10%) maximum lifespan. Enhanced ageing-related traits like impaired hair growth, increased bone loss, and reduced body fat content.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Casp2 loss of function