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Observation 1993

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Species Mus musculus
Strain
Lifespan
Reference Lifespan
Lifespan Change 12%
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation Baker DJ, Jeganathan KB, Malureanu L, Perez-Terzic C, Terzic A, van Deursen JM. (2006). Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.. J. Cell Biol. 172: 529-40. [pubmed]
Details
Haploinsufficiency of Bub3 and Rae1 reduces lifespan by 12% and appears to accelerate ageing.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Bub3 loss of function
Rae1 loss of function