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Observation 1992

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Species Mus musculus
Strain
Lifespan 6
Reference Lifespan 15
Lifespan Change -60%
Lifespan Measure mean
Lifespan Effect decreased
Significance significant
Citation Baker DJ, Jeganathan KB, Cameron JD, Thompson M, Juneja S, Kopecka A, Kumar R, Jenkins RB, de Groen PC, Roche P, van Deursen JM. (2004). BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice.. Nat. Genet. 36: 744-9. [pubmed]
Details
Knockout mutant mice exhibit a minimum of 60% shorter lifespan. Also exhibit lordokyphosis and fat loss.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Bub1b loss of function