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Observation 1991

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Species Mus musculus
Strain Brca1Δ11/Δ11 p53 +/−
Lifespan 9
Reference Lifespan 12
Lifespan Change -25%
Lifespan Measure mean
Lifespan Effect decreased
Significance significant
Citation Cao L, Li W, Kim S, Brodie SG, Deng CX. (2003). Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform.. Genes Dev. 17: 201-13. [pubmed]
Deletion causes senescence in mutant embryos and cultured cells and tumorigenesis and signs of premature ageing in adult mice. Adult mice showed approximately 24% decreased lifespan.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Brca1 deletion / null