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Observation 1936

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Species Drosophila melanogaster
Strain UCP5KO
Sex female
Temperature 25
Lifespan 10.5 days
Reference Lifespan 11.4 days
Lifespan Change -7.89%
Lifespan Measure mean
Lifespan Effect decreased
Significance significant
Citation Sánchez-Blanco A, Fridell YW, Helfand SL. (2006). Involvement of Drosophila uncoupling protein 5 in metabolism and aging. Genetics 172: 1699-710. [pubmed]
Knockout flies live longer than controls on low-calorie diets, but not longer than controls on starvation or high-calorie diets. Female knock-outs had shortened lifespan on 1% Y–S DIET.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Bmcp loss of function