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Observation 1935

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Species Mus musculus
Strain WW6/C57BL/6
Lifespan 12.5
Reference Lifespan 20
Lifespan Change -37.5%
Lifespan Measure mean
Lifespan Effect decreased
Significance significant
Citation Wong KK, Maser RS, Bachoo RM, Menon J, Carrasco DR, Gu Y, Alt FW, DePinho RA. (2003). Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing.. Nature 421: 643-8. [pubmed]
Mice mutant for Atm and Terc displayed accelerated ageing, 37% shorter than wild type. Other phenotypes: Mice mutant for Atm and Terc displayed progressive multi-organ system compromise and features of accelerated ageing.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Atm deletion / null