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Observation 1930

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Species Mus musculus
Strain
Lifespan 259 days
Reference Lifespan 730 days
Lifespan Change -64.52%
Lifespan Measure
Lifespan Effect decreased
Significance significant
Citation Kondratov RV, Kondratova AA, Gorbacheva VY, Vykhovanets OV, Antoch MP. (2006). Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock.. Genes Dev. 20: 1868-73. [pubmed]
Details
The average lifespan for KO animals was 200% shorter than wild-type. Other phenotypes: Knockout mice display symptoms of premature ageing including a shorter lifespan, sarcopenia, cataracts, less subcutaneous fat, and organ shrinkage.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Arntl deletion / null