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Observation 191

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Species Mus musculus
Strain
Lifespan
Reference Lifespan
Lifespan Change 50%
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation Wang L, Yang L, Debidda M, Witte D, Zheng Y. (2007). Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.. Proc. Natl. Acad. Sci. U.S.A. 104: 1248-53. [pubmed]
Details

Animals that survived had a 50% shorter lifespan.

Other phenotypes: Most knockout mice were weak and died during the neonatal period. Animals that survived had a shorter lifespan (median lifespan was 12 months) and showed premature ageing-like phenotypes, including a reduction in body mass, a loss of subdermal adipose tissue, lordokyphosis, and osteoporosis.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Arhgap1 deletion / null 228359 View