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Observation 1861

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Species Mus musculus
Strain AKR/J
Lifespan 243 days
Reference Lifespan 230 days
Lifespan Change 5.65%
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation Shin SC, Kang YM, Kim HS. (2010). Life Span and Thymic Lymphoma Incidence in High- and Low-Dose-Rate Irradiated AKR/J Mice and Commonly Expressed Genes. :. [pubmed]
Details
To evaluate the effect of low-dose-rate radiation on cancer incidence, short-lived AKR/J mice were housed in a long-term low-dose-rate irradiation facility ((137)Cs, 0.07 cGy/h). Thymic lymphoma incidence and life span were compared withmice irradiated at a high dose rate ((137)Cs, 0.8Gy/min, total dose of 4.5 Gy) and nonirradiated mice. The average life span of the low-dose-rate irradiated mice (243 days) was longer than those of the high-dose-rate irradiated mice (208 days) and nonirradiated mice (230 days) (P = 0.02). The incidence of thymic lymphoma in low-dose-rate irradiated mice was lower than that in nonirradiated mice and high-dose-rate irradiated mice by 10 and 20%, respectively (P < 0.01).

Environment Interventions

Type Body
irradiation Animals housed at a long-term low dose irradiation facility ((137)Cs, 0.07 cGy/h).