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Observation 182

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Species Mus musculus
Strain
Lifespan
Reference Lifespan
Lifespan Change 30%
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation Yan L, Vatner DE, O'Connor JP, Ivessa A, Ge H, Chen W, Hirotani S, Ishikawa Y, Sadoshima J, Vatner SF. (2007). Type 5 adenylyl cyclase disruption increases longevity and protects against stress.. Cell 130: 247-58. [pubmed]
Details

Knock out mice are resistant have an increased median lifespan of 30%.

Other phenotypes: Increased maximal lifespan of 12%. They are also protected from age-related reduced bone density and susceptibility to fractures, and reduced cardiac function.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
Adcy5 deletion / null 224129 View