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Observation 18

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Species Saccharomyces cerevisiae
Strain PSY316
Mating Type matalpha
Temperature 30
Lifespan 7.1 divisions
Reference Lifespan 23.5 divisions
Lifespan Change -69.79%
Lifespan Measure mean
Lifespan Effect decreased
Significance significant
Citation Park PU, Defossez PA, Guarente L. (1999). Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae.. Mol. Cell. Biol. 19: 3848-56. [pubmed]
Details

Deletion or RAD52 causes a 75% reduction in mean life span in strain PSY316.

Other phenotypes: Required for formation of extrachromosomal rDNA circles [pubmed], but not for replication fork pausing nor DNA breakage within the rDNA [pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
RAD52 deletion / null 854976 View