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Observation 177

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Species Podospora anserina
Strain s
Reference Lifespan
Lifespan Change
Lifespan Measure
Lifespan Effect increased
Significance significant
Citation Begel O, Boulay J, Albert B, Dufour E, Sainsard-Chanet A. (1999). Mitochondrial group II introns, cytochrome c oxidase, and senescence in Podospora anserina.. Mol. Cell. Biol. 19: 4093-100. [pubmed]

Deletion of mobile group II intron (intron alpha) from COX1 doubled lifespan.

Other phenotypes: Deletion encompassing intron alpha and its upstream exon abolished the senescence process entirely [pubmed]. Deletion of the PaCOX1 intron-alpha prevented accumulation of senescence-associated DNA concatemer corresponding to this region of the mitochondrial genome [pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
COX1 deletion / null 854598 View