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Observation 17

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Species Saccharomyces cerevisiae
Strain PSY316
Mating Type matalpha
Temperature 30
Lifespan 13
Reference Lifespan 23
Lifespan Change -43.48%
Lifespan Measure
Lifespan Effect decreased
Significance significant
Citation Park PU, Defossez PA, Guarente L. (1999). Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae.. Mol. Cell. Biol. 19: 3848-56. [pubmed]

Deletion causes a 40% reduction in mean life span in strain PSY316.

Other phenotypes: Rad51p is required for gene conversion, but not for repair of an HO-induced double-strand break [pubmed]. Deletion of rad51 decreases formation of extrachromosomal rDNA circles [pubmed].

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
RAD51 deletion / null 856831 View