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Observation 167

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Species Drosophila melanogaster
Strain
Lifespan
Reference Lifespan
Lifespan Change
Lifespan Measure
Lifespan Effect decreased
Significance significant
Citation Finley KD, Edeen PT, Cumming RC, Mardahl-Dumesnil MD, Taylor BJ, Rodriguez MH, Hwang CE, Benedetti M, McKeown M. (2003). blue cheese mutations define a novel, conserved gene involved in progressive neural degeneration.. J. Neurosci. 23: 1254-64. [pubmed]
Details

Mutation of beach1 results in a 40-45% decrease in mean life-span.

Other phenotypes: Beach1 mutants display an age-related neurodegenerative phenotype with reduced CNS size and altered morphology [pubmed]. Mutation of beach1 also results in an accumulation of insoluble ubiquinated proteins and amyloid precursor-like proteins

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
beach1 deletion / null