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Observation 160

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Species Saccharomyces cerevisiae
Strain W303AR5
Mating Type mata
Temperature 30
Lifespan 22 divisions
Reference Lifespan 22 divisions
Lifespan Change
Lifespan Measure mean
Lifespan Effect decreased
Significance significant
Citation Imai S, Armstrong CM, Kaeberlein M, Guarente L. (2000). Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase.. Nature 403: 795-800. [pubmed]
Mutation of Sir2 asparagine 345 to alanine modestly decreased activity but did not shorten life span.

Gene Interventions:

Symbol Allele Allele Type NCBI Gene ID More
SIR2 R345A loss of function
HML deletion / null